Cortical pyramidal cells as non-linear oscillators: Experiment and spike-generation theory

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Cortical pyramidal cells as non-linear oscillators: experiment and spike-generation theory.

Cortical neurons are capable of generating trains of action potentials in response to current injections. These discharges can take different forms, e.g., repetitive firing that adapts during the period of current injection or bursting behaviors. We have used a combined experimental and computational approach to characterize the dynamics leading to action potential responses in single neurons. ...

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Pyramidal cells and interneurons in rat prefrontal cortical slices exhibit subthreshold oscillations when depolarized by constant current injection. For both types of neurons, the frequencies of these oscillations for current injection just below spike threshold were 2--10 Hz. Above spike threshold, however, the subthreshold oscillations in pyramidal cells remained low, but the frequency of osc...

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ژورنال

عنوان ژورنال: Brain Research

سال: 2007

ISSN: 0006-8993

DOI: 10.1016/j.brainres.2007.07.028